AU-binding factor 1 expression was correlated with metadherin expression and progression of hepatocellular carcinoma

作者：Yang Yingzhuo; Kang Peng; Gao Jie; Xu Chunlin; Wang Shimei; Jin Haiyu; Li Yunling; Liu Wenjuan; Wu Xia^*

来源：Tumor Biology, 2014, 35(3): 2747-2751.

DOI：10.1007/s13277-013-1362-2

• Hepatocellular carcinoma
• RNA-binding factor 1
• Metadherin (MTDH)
• Biomarker

RNA-binding factor 1 (AUF1) was found to be up-regulated in numerous tumors compared with untransformed tissues. Furthermore, it has been identified to regulate mRNAs en masse in hepatocellular carcinoma (HCC). Metadherin (MTDH) as a novel oncogene also promotes tumor progression and metastasis in HCC. Our study aimed to investigate the correlation between AUF1 and MTDH expressions by immunochemistry in 146 HCC patients from Heilongjiang region. AUF1 expression in HCC tumors was higher than that in the matched normal liver tissues. Particularly, AUF1 overexpression was closely associated with tumor size (P < 0.022), TNM stage (P < 0.003), hepatitis B surface antigen status, and AFP serum levels (P < 0.05). Furthermore, AUF1 overexpression led to poor outcome during 5-year follow-up (P < 0.001). Additionally, AUF1 and MTDH expressions were correlated with each other. Our findings suggest that the AUF1 gene may play an important role in HCC progression and be a novel biomarker in the future.

• 出版日期2014-3
• 单位哈尔滨医科大学