A novel flow-injection chemiluminescence method for determination of baclofen using L-cysteine capped CdS quantum dots

作者：Khataee Alireza^*; Hasanzadeh Aliyeh; Iranifam Mortaza; Joo Sang Woo

来源：Sensors and Actuators B: Chemical , 2015, 215: 272-282.

DOI：10.1016/j.snb.2015.03.066

• CdS quantum dots
• Nanocatalyst
• Chemiluminescence
• Flow injection
• Baclofen

L-Cysteine capped CdS quantum dots (QDs) were synthesized through a facile hydrothermal method and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photoluminescence (PL), and UV-vis spectroscopy. The L-cysteine capped CdS QDs sample displayed chemiluminescence (CL) emission in reaction with KMnO4 in acidic medium. It was found that the CL intensity of KMnO4-L-cysteine capped CdS QDs CL system was remarkably enhanced in the presence of Na2S2O3. Furthermore, the possible CL mechanism was presented for this CL reaction according to results of the kinetic curves of CL systems, the spectra of CL, PL and UV-vis. The CL intensity of KMnO4-L-cysteine capped CdS QDs-Na2S2O3 was strongly inhibited in the presence of baclofen. Based on this inhibition, a novel and sensitive flow-injection CL method was developed for the determination of baclofen. Under optimum conditions, the CL intensity was inversely proportional to the concentration of baclofen in the range of 0.012-24.0 mg L-1, with a detection limit (3 sigma) of 0.0035 mg L-1. The analytical applicability of the proposed CL system was assessed by determining baclofen in spiked environmental water samples and pharmaceutical formulation. The analytical performances of proposed flow-injection CL method for the determination of baclofen were compared with those obtained by corona discharge ionization ion mobility spectrometry (CD-IMS) method. The proposed CL system had a higher sensitivity than the CD-IMS method for the determination of baclofen.

• 出版日期2015-8