Association between the angiotensin I-converting enzyme gene insertion/deletion polymorphism and endurance running speed in Japanese runners

作者：Tobina, Takuro^*; Michishita, Ryoma; Yamasawa, Fumihiro; Zhang, Bo; Sasaki, Hideo; Tanaka, Hiroaki; Saku, Keijiro; Kiyonaga, Akira

来源：Journal of Physiological Sciences, 2010, 60(5): 325-330.

DOI：10.1007/s12576-010-0100-4

• Angiotensin I-converting enzyme
• Gene polymorphism
• Endurance performance
• Genetic factor

We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and endurance running performance in Japanese elite runners, including several Olympic athletes. The frequency of the I/I genotype was not significantly higher and the frequency of the D/D genotype was not significantly lower in elite runners compared with non-athletes. However, the frequency of the I/D genotype tended to be lower in elite runners than in non-athletes. The best performance was significantly higher for runners with the D/D genotype than for those with the I/I genotype, and the average running speed was significantly higher for those with the combined D/D + I/D genotypes than for those with the I/I genotype. There were no I/I genotypes among the five fastest marathon runners. These results suggest that the D allele of the ACE gene I/D polymorphism is associated with a high level of human endurance.

• 出版日期2010-9