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摘要
A novel, effective 1-glycyl-3-methyl imidazolium chloridepalladium(II) complex ([Gmim]ClPd(II)) was synthesized and studied as an organocatalyst for the Sonogashira coupling reaction under solvent-free conditions at 25 degrees C. The hydrophobic group on amino acid favors reagent diffusion toward the chloroglycine moiety, increasing the catalytic activity of supported palladium complex. By this protocol, different aryl halides (Cl, Br and I) were reacted with phenylacetylene in good to excellent yields with turnover number 8.0 x 102 to 9.6 x 102. The catalyst was recycled for the reaction of bromobenzene with phenylacetylene for eight runs without appreciable loss of its catalytic activity and negligible metal leaching.
- 出版日期2012-11
