Antigenic and Genetic Diversity of Highly Pathogenic Avian Influenza A (H5N1) Viruses Isolated in Egypt

作者：Balish Amanda L; Davis C Todd; Saad Magdi D; El Sayed Nasr; Esmat Hala; Tjaden Jeffrey A; Earhart Kenneth C; Ahmed Lu'ay E; Abd El Halem Mohamed; Ali Abdel Hakem M; Nassif Samir A; El Ebiary Elham A; Taha M; Aly Mona M; Arafa Abdelstattar; O'Neill Eduardo; Xu Xiyan; Cox Nancy J; Donis Ruben O^*; Klimov Alexander I

来源：Avian Diseases, 2010, 54(1): 329-334.

DOI：10.1637/8903-042909-Reg.1

• HPAI
• H5N1
• Egypt
• clade 2.2
• pandemic
• vaccine

Highly pathogenic avian influenza A virus (H5N1) has diverged antigenically and genetically since its initial detection in Asia in 1997. Viruses belonging to clade 2.2 in particular have been reported in numerous countries with the majority occurring in Egypt. Previous reports identified antigenic similarities between viruses belonging to clack 2.2. However, poultry and human viruses isolated in northern Egypt during 2007 and 2008 were found to he antigenically distinct from other clade 2.2 viruses from this country. Genetic analysis of the hemagglutinin revealed a high degree of nucleotide and ammo acid divergence. The antigenic changes in Egyptian viruses isolated during 2007-08 necessitated that two of these strains be considered as potential H5N1 pre-pandemic vaccine candidates.

• 出版日期2010-3