A novel one pot multi-component strategy for facile synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones

作者：Mane M M; Pore D M^*

来源：Tetrahedron Letters, 2014, 55(48): 6601-6604.

DOI：10.1016/j.tetlet.2014.10.052

• Multi-component
• Aldehyde
• Hydrazine hydrate
• Trimethylsilyl isothiocyanate
• 5-Aryl-[1,2,4]triazolidine-3-thiones

We have disclosed an efficient, one pot, novel multi-component approach for the synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones from aldehyde, hydrazine hydrate, and trimethylsilyl isothiocyanate (TMSNCS) in the presence of catalytic amount of sulfamic acid. High yields, easy work-up procedure, no chromatographic separation, and novelty in multi-component strategy are the main merits of the present strategy.

• 出版日期2014-11-26