科研之友
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摘要
Mitochondrial genome instability and associated diseases Some cases of mitochondrial diseases are due to mitochondrial DNA instability. multiple deletions or depletions These anomalies are responsible for Q mitochondrial respiratory chain impairment leading to various clinical involvements ranging from mild features with multiple mtDNA deletions to severe organ failure and premature death caused by mtDNA depletions Both, deletions and depletions share an important and common feature between these two specificities indeed, both are expressed in a tissue-specific manner
- 出版日期2010-2
