A Great Barrier Reef Sinularia sp Yields Two New Cytotoxic Diterpenes

作者：Wright Anthony D; Nielson Jonathan L; Tapiolas Dianne M; Liptrot Catherine H; Motti Cherie A^*

来源：Marine Drugs, 2012, 10(8): 1619-1630.

DOI：10.3390/md10081619

• Sinularia
• Alcyoniidae
• anticancer activity
• lobane
• cembrane
• diterpene

The methanol extract of a Sinularia sp., collected from Bowden Reef, Queensland, Australia, yielded ten natural products. These included the new nitrogenous diterpene (4R*, 5R*, 9S*, 10R*, 11Z)-4-methoxy-9-((dimethylamino)-methyl)-12,15-epoxy-11 (13)-en-decahydronaphthalen-16-ol (1), and the new lobane, (1R*, 2R*, 4S*, 15E)-loba-8,10, 13(14), 15(16)-tetraen-17,18-diol-17-acetate (2). Also isolated were two known cembranes, sarcophytol-B and (1E,3E,7E)-11, 12-epoxycembratrien-15-ol, and six known lobanes, loba-8, 10,13(15)-triene-16,17,18-triol, 14,18-epoxyloba-8,10,13(15)-trien-17-ol, lobatrientriol, lobatrienolide, 14,17-epoxyloba-8,10,13(15)-trien-18-ol-18-acetate and (17R)-loba-8,10,13 (15)-trien-17,18-diol. Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The tumour cell growth inhibition potential of 1 and 2 along with loba-8,10,13(15)-triene-16,17,18-triol, 14,17-epoxyloba-8,10,13 (15)-trien-18-ol-18-acetate, lobatrienolide, (1E,3E,7E)-11,12-epoxycembratrien-15-ol and sarcophytol-B were assessed against three human tumour cell lines (SF-268, MCF-7 and H460). The lobanes and cembranes tested demonstrated 50% growth inhibition in the range 6.8-18.5 mu M, with no selectivity, whilst 1 was less active (GI(50) 70-175 mu M).

• 出版日期2012-8