Drug-resistant tuberculosis in two children in Greece: Report of the first extensively drug-resistant case

作者：Katragkou Aspasia; Antachopoulos Charalampos; Hatziagorou Elpis; Sdougka Maria; Roilides Emmanuel^*; Tsanakas John

来源：European Journal of Pediatrics, 2013, 172(4): 563-567.

DOI：10.1007/s00431-012-1811-8

• Tuberculosis
• Children
• Extensively drug-resistant
• Multidrug-resistant
• Pneumonia
• Central nervous system

Extensively drug-resistant (XDR) tuberculosis (TB) represents a serious and growing problem in both endemic and non-endemic countries. We describe a 2.5-year-old girl with XDR-pulmonary TB and an 18-month-old boy with pre-XDR-central nervous system TB. Patients received individualized treatment with second-line anti-TB agents based on genotypic and phenotypic drug susceptibility testing results. Both children achieved culture conversion 3 months and 1 month after treatment initiation, respectively. The child with XDR-pulmonary TB showed evidence of cure while treatment adverse events were managed without treatment interruption. The child with pre-XDR-central nervous system TB after 6-month hospitalization with multiple infectious complications had a dismal end due to hepatic insufficiency possibly related to anti-TB treatment. This is the first report of children with pre-XDR and XDR TB in Greece, emphasizing the public health dimensions and management complexity of XDR TB.

• 出版日期2013-4