科研之友
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摘要
Based on a reaction of ninhydrin with phenols, a new embelin-ninhydrin adduct has been synthesized and characterized. The adduct exhibits high antioxidant activity in the DPPH test. The analgesic and anti-inflammatory activity was also found to be better than that of the parent compound (embelin). In the acetic-acid-induced writhing test, almost complete abolition of writhing was observed at 10 and 20 mg/(kg body weight) doses of embelin-ninhydrin adduct and the results were better than those achieved with the standard drug pentazocine.
- 出版日期2011-11
