Analysis of CD34+ Cell Collection Using Two Mobilization Regimens for Newly Diagnosed Multiple Myeloma Patients Reveals the Separate Impact of Mobilization and Collection Variables

作者：Abuabdou Ahmed; Rosenbaum Eric R; Usmani Saad Zafar; Barlogie Bart; Cottler Fox Michele^*

来源：Journal of Clinical Apheresis, 2014, 29(5): 251-255.

DOI：10.1002/jca.21313

• CD34+
• mobilization
• apheresis
• myeloma
• melphalan

Mobilization regimens for CD34+ cells have generally been judged successful based on the number of cells collected without evaluating mobilization separately from collection. Using retrospective data for patients who collected CD34+ cells on Total Therapy protocols 3a/3b (VTD-PACE) and Total Therapy 4/5 using a novel regimen that added low dose melphalan to VTD-PACE (MVTD-PACE), we analyzed mobilization and collection variables separately. A significant difference favoring MVDT-PACE was found in mean CD34+ cells/mu L on day 2 of collection and in mean ratio of CD34+ cells/mu L on day 2 to day 1. However, because apheresis variables and growth factor dose during collection were manipulated to optimize individual collections, the two regimens were not significantly different when the mean total CD34+ cells x10(6)/kg collected was compared. Thus, when evaluating a chemotherapy regimen or new growth factor for mobilization, it is important to realize that total CD34+ cells collected is dependent on both mobilization and collection variables. J. Clin. Apheresis 29:251-255, 2014.

• 出版日期2014-10