科研之友
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摘要
Polycyclic aromatic hydrocarbons (PAHs) are well-known carcinogenic and endocrine disrupting chemicals that have been concerned over the past few decades. We aimed to determine the hydroxylated PAH (OHPAH) metabolite concentrations in maternal urine collected from the e-waste-contaminated area of Guiyu and the reference area of Haojiang, China, and to evaluate their health effects on birth outcomes. The median Sigma OHPAH concentration was 6.87 mu g/g creatinine from Guiyu, and 3.90 mu g/g creatinine from Haojiang. 2-OHNap and 1-OHPyr were the predominant metabolites. Residence in Guiyu and recycling in houses were associated with elevated 2-OHNap and 1-OHPyr. Standardized mean difference revealed that compared to low PAH metabolite levels in the first quartile, high PAH metabolite levels in the fourth quartile especially for 1-OHPyr, Sigma OHPAHs and sometimes hydroxylphenanthrene compounds, presented a reduced size in birth outcomes (overall SMD: -0.09; 95% CI: -0.15, -0.03), including head circumference, BMI and Apgar 1 score, and increased size in height. After adjusting for confounders in regression models, an interquartile increase in Sigma OHPAHs was associated with a decrease of 234.56 g in weight (95% CI: -452.00, -17.13), 1.72 cm in head circumference (95% CI: -2.96, -0.48), 1.06 kg/m(2) in BMI (95% CI: -1.82, -0.31) and 0.42 in Apgar 1 score (95% CI: -0.66, -0.18), respectively. These findings suggest high exposure to PAHs during pregnancy in e-waste areas, posing a potential threat to neonatal development, which likely can be attributed to direct e-waste recycling activities. Ongoing studies should be continued to monitor human exposure and health, in particular for vulnerable individuals in e-waste-polluted areas.
