(HMe2SiCH2)2: A Useful Reagent for B(C6F5)3-Catalyzed Reduction-Lactonization of Keto Acids: Concise Syntheses of (-)-cis-Whisky and (-)-cis-Cognac Lactones

作者：Xie, Hengmu; Lu, Ji; Gui, Yingying; Gao, Lu; Song, Zhenlei^*

来源：Synlett, 2017, 28(18): 2453-2459.

DOI：10.1055/s-0036-1588488

• lactonization
• reduction
• silanes
• B(C6F5)(3)
• keto acids

(HMe2SiCH2)(2) has been utilized as a useful reagent for B(C6F5)(3)-catalyzed reduction-lactonization of keto acids to synthesize gamma and delta-lactones. The process led concisely to (-)-cis-whisky and (-)-ciscognac lactones in respective overall yields of 32% and 36%.

• 出版日期2017-11
• 单位四川大学; 南开大学