Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway

作者：Choi Seung Hee; Kim Hwa Young^*

来源：Biochemical and Biophysical Research Communications, 2011, 416(1-2): 70-75.

DOI：10.1016/j.bbrc.2011.10.145

• Methionine sulfoxide reductase
• MsrA
• Cell proliferation
• Cell cycle
• p21

MsrA is an oxidoreductase that catalyzes the stereospecific reduction of methionine-S-sulfoxide to methionine. Although MsrA is well-characterized as an antioxidant and has been implicated in the aging process and cellular senescence, its roles in cell proliferation are poorly understood. Here, we report a critical role of MsrA in normal cell proliferation and describe the regulation mechanism of cell growth by this protein. Down-regulation of MsrA inhibited cell proliferation, but MsrA overexpression did not promote it. MsrA deficiency led to an increase in p21, a major cyclin-dependent kinase inhibitor, thereby causing cell cycle arrest at the G(2)/M stage. While protein levels of p53 were not altered upon MsrA deficiency, its acetylation level was significantly elevated, which subsequently activated p21 transcription. The data suggest that MsrA is a regulator of cell growth that mediates the p53-p21 pathway.

• 出版日期2011-12-9