D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified poly(L-lactide) (PLLA) films for localized delivery of paclitaxel

作者：Dong Yuancai; Zhang Zhiping; Feng Si Shen^*

来源：International Journal of Pharmaceutics, 2008, 350(1-2): 166-171.

DOI：10.1016/j.ijpharm.2007.08.043

• anticancer drugs
• antiproliferative drugs
• biodegradable films
• biodegradable polymers
• controlled release
• localized drug delivery

D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) was used as a novel additive to the poly(L-lactide) (PLLA) films for local drug delivery with paclitaxel as a prototype therapeutic agent. Paclitaxel-loaded PLLA/TPGS films were prepared by the solvent casting technique with dichloromethane as the solvent. Effects of TPGS component on the films'; physicomechanical properties and the drug release profile were investigated. It was found by field emission scanning microscopy (FESEM) that a biphasic honeycomb surface was formed for the PLLA/TPGS films, while the PLLA film exhibited a smooth and homogeneous surface. There was no significant effect of the drug loading on the morphological structure of the PLLA/TPGS films. Differential scanning calorimetry (DSC) demonstrated that the PLLA/TPGS films was a phase-separated system. Tensile testing showed that the flexibility of the PLLA/TPGS films was much higher than that of the PLLA film. The elongation at break for the PLLA/TPGS film of 5%, 10% and 15% TPGS content was 6.8, 8.9 and 19.4 times of that for the PLLA film, respectively. In vitro drug release studies found that incorporation of TPGS considerably facilitated paclitaxel release.

• 出版日期2008-2-28