科研之友
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摘要
BackgroundThere is limited longitudinal data from high-income countries on the sequelae of anaemia during pregnancy. The aim of this study is to examine whether anaemia of pregnancy is associated with adverse perinatal outcomes and with children%26apos;s developmental vulnerability. %26lt;br%26gt;MethodsWe conducted a population-based study to link routinely collected government administrative data that involved all live births in the state of South Australia 1999-2005 (n=124061) and a subset for whom developmental data were collected during a national census of children attending their first year of school in 2009 (n=13654). Perinatal outcomes were recorded by midwives using a validated, standardised form. Development was recorded by schoolteachers using the Australian Early Development Index (AEDI). Children in the lowest 10% of AEDI scores are indicative of developmental vulnerability. %26lt;br%26gt;ResultsThere were 8764/124061 (7.1%) cases of anaemia. After adjustment for a range of potentially confounding factors, anaemia of pregnancy was associated with a higher risk of fetal distress [incident rate ratio (IRR) 1.20 [95% CI 1.13, 1.27]] and preterm birth %26lt;37 weeks gestation (IRR 1.23 [1.15, 1.31]), slightly higher birthweight [14g (2, 26)] and newborns were less likely to require resuscitation (IRR 0.94 [0.91, 0.097]). Anaemia of pregnancy was not associated with children%26apos;s developmental vulnerability after adjustment for maternal, obstetric and sociodemographic covariables, either in complete case analyses (n=11949) or after imputation for missing data (n=13654). %26lt;br%26gt;ConclusionsAnaemia of pregnancy is associated with perinatal complications but not with children%26apos;s developmental vulnerability at school entry.
- 出版日期2014-9
