Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) study

作者：Tian Niu^*; Penman Alan D; Mawson Anthony R; Manning R Davis Jr; Flessner Michael F

来源：Journal of the American Society of Hypertension, 2010, 4(6): 272-283.

DOI：10.1016/j.jash.2010.09.005

• Inflammation
• hypertension
• neutrophil
• lymphocyte

Although total white blood cell (WBC) count has been associated with hypertension, the association between specific WBC types and blood pressure (BP) levels has not been studied. In a cohort of 5746 middle-age African-American and white adults free of clinical cardiovascular disease and cancer and not taking hypertension or anti-inflammatory medications, BP was measured at baseline and 3, 6, and 9 years later. Levels of circulating neutrophils, lymphocytes, and monocytes were measured at baseline. In African-Americans, but much less so in whites, increased neutrophil levels and decreased lymphocyte levels were significantly associated with elevation of BP but did not influence the rate of change of BP over time. The mean BP difference between the highest and lowest quartiles of neutrophils was approximately 8 mm Hg for systolic BP (SBP), 4 mm Hg for mean arterial pressure (MAP), and 5 mm Hg for pulse pressure (PP). The mean BP difference between the lowest and highest quartiles of lymphocytes was approximately 6 mm Hg for SBP, 2 mm Hg for diastolic BP (DBP), 3 mm Hg for MAP, and 4 mm Hg for PR Increased neutrophils and decreased lymphocytes are significantly correlated with the regulation of BP and the development of hypertension, especially in African-Americans. J Am Soc Hypertens 2010;4(6):272-283.

• 出版日期2010-12