Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins

作者：Tache Andreia; Radu Gabriel Lucian^*; Litescu Simona Carmen

来源：CHEMICAL PAPERS, 2012, 66(12): 1166-1170.

DOI：10.2478/s11696-012-0233-4

• lipoproteins
• peroxyl radicals
• hydroxyl radicals
• copper ion
• antioxidant

This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals' concentration over a range of 10(-6)-10(-5) mol L-1. Cu2+ accentuates lipoperoxidation but, when rosmarinic acid was present, Cu2+ produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu2+ and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1.

• 出版日期2012-12