3,5-Diacetyl-1,2,4-triazol bis(N-4-substituted thiosemicarbazone) palladium(II) complexes: Synthesis, structure, antiproliferative activity and low toxicity on normal kidney cells

作者：Matesanz Ana I; Hernandez Carolina; Rodriguez Ana; Souza Pilar^*

来源：Journal of Inorganic Biochemistry, 2011, 105(12): 1613-1622.

DOI：10.1016/j.jinurgbio.2011.08.014

• Antitumour agents
• Palladium complexes
• Renal toxicity
• Thiosemicarbazone
• 1,2,4-Triazol
• X-ray diffraction

Treatment of N-4-monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series with lithium tetrachloridopalladate gave the dinuclear complexes of general formula [Pd(mu-H3L1-5)12, but using dichloridobis-triphenylphosphinepalladium(II) salt, the first mononuclear bis(thiosemicarbazone)-palladium-triphenylphosphine complexes of the 3,5-diacety1-1,2,4-triazol series, [Pd(H3L1-5)PPh3], have been obtained. All the compounds have been characterized by elemental analysis and by IR and NMR spectroscopy. and the crystal and molecular structures of dinuclear complexes [Pd(mu-H3L3)](2) and Pd(mu-H3L5)](2) as well as mononuclear complexes [Pd(H3L1)PPh3], [Pd(H3L2)PPh3], [Pd(H3L3)PPh3] and Pd(H3L4)PPh3] have been determined by X-ray crystallography. The new compounds synthesized have been evaluated for antiproliferative activity in vitro against NCl-H460, A2780 and A2780cisR human cancer cell lines. Subsequent toxicity study, on normal renal LLC-PK1 cells, shows that all compounds investigated exhibit very low toxicity on kidney cells with respect to cisplatin.

• 出版日期2011-12