A comparison of nine scales to detect depression in Parkinson disease Which scale to use?

作者：Williams J R; Hirsch E S; Anderson K; Bush A L; Goldstein S R; Grill S; Lehmann S; Little J T; Margolis R L; Palanci J; Pontone G; Weiss H; Rabins P; Marsh L^*

来源：Neurology, 2012, 78(13): 998-1006.

DOI：10.1212/WNL.0b013e31824d587f

Objective: The Methods of Optimal Depression Detection in Parkinson%26apos;s Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide guidance on scale selection in Parkinson disease (PD). %26lt;br%26gt;Methods: Patients with PD (n = 229) from community-based neurology practices completed 6 self-report scales (Beck Depression Inventory [BDI]-II, Center for Epidemiologic Studies Depression Rating Scale-Revised [CESD-R], 30-item Geriatric Depression Scale [GDS-30], Inventory of Depressive Symptoms-Patient [IDS-SR], Patient Health Questionnaire-9 [PHQ-9], and Unified Parkinson%26apos;s Disease Rating Scale [UPDRS]-Part I) and were administered 3 clinician-rated scales (17-item Hamilton Depression Rating Scale [HAM-D-17], Inventory of Depressive Symptoms-Clinician [IDS-C], and Montgomery-angstrom sberg Depression Rating Scale [MADRS] and a psychiatric interview. DSM-IV-TR diagnoses were established by an expert panel blinded to the self-reported rating scale data. Receiver operating characteristic curves were used to estimate the area under the curve (AUC) of each scale. %26lt;br%26gt;Results: All scales performed better than chance (AUC 0.75-0.85). Sensitivity ranged from 0.66 to 0.85 and specificity ranged from 0.60 to 0.88. The UPDRS Depression item had a smaller AUC than the BDI-II, HAM-D-17, IDS-C, and MADRS. The CESD-R also had a smaller AUC than the MADRS. The remaining AUCs were statistically similar. %26lt;br%26gt;Conclusions: The GDS-30 may be the most efficient depression screening scale to use in PD because of its brevity, favorable psychometric prope

• 出版日期2012-3