Automated identification of normal and diabetes heart rate signals using nonlinear measures

作者：Acharya U Rajendra; Faust Oliver^*; Kadri Nahrizul Adib; Suri Jasjit S; Yu Wenwei

来源：Computers in Biology and Medicine, 2013, 43(10): 1523-1529.

DOI：10.1016/j.compbiomed.2013.05.024

• Diabetes mellitus
• Electrocardiogram Heart rate variability
• Recurrence plots
• Approximate Entropy
• Largest Lyapunov exponet
• Detrended fluctuation analysis
• AdaBoost Decision tree
• Fuzzy Sugeno classifier
• k-Nearest neighbor algorithm
• Probabilistic neural network
• Support vector machine

Diabetes mellitus (DM) affects considerable number of people in the world and the number of cases is increasing every year. Due to a strong link to the genetic basis of the disease, it is extremely difficult to cure. However, it can be controlled to prevent severe consequences, such as organ damage. Therefore, diabetes diagnosis and monitoring of its treatment is very important. In this paper, we have proposed a non-invasive diagnosis support system for DM. The system determines whether or not diabetes is present by determining the cardiac health of a patient using heart rate variability (HRV) analysis. This analysis was based on nine nonlinear features namely: Approximate Entropy (ApEn), largest Lyapunov exponet (LLE), detrended fluctuation analysis (DFA) and recurrence quantification analysis (RQA). Clinically significant measures were used as input to classification algorithms, namely AdaBoost, decision tree (DT), fuzzy Sugeno classifier (FSC), k-nearest neighbor algorithm (k-NN), probabilistic neural network (PNN) and support vector machine (SVM). Ten-fold stratified cross-validation was used to select the best classifier. AdaBoost, with least squares (LS) as weak learner, performed better than the other classifiers, yielding an average accuracy of 90%, sensitivity of 92.5% and specificity of 88.7%.

• 出版日期2013-10-1
• 单位天津大学