Anoctamins

作者：Kunzelmann Karl^*; Tian Yuemin; Martins Joana Raquel; Faria Diana; Kongsuphol Patthara; Ousingsawat Jira****; Thevenod Frank; Roussa Eleni; Rock Jason; Schreiber Rainer

来源：Pflugers Archiv-European Journal of Physiology, 2011, 462(2): 195-208.

DOI：10.1007/s00424-011-0975-9

• Ca2+-activated Cl- currents
• CaCC
• TMEM16A
• Ano 1
• Anoctamin
• TMEM16B
• TMEM16E
• TMEM16F
• TMEM16G
• TMEM16H
• TMEM16J
• TMEM16K
• Cystic fibrosis
• Proliferation
• Cancer
• Development, SHH

Endogenous Ca2+-activated Cl-channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1-10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca2+-activated Cl- currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.

• 出版日期2011-8