Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

作者：Rouault Tracey A^*; Zhang De Liang; Jeong Suh Young

来源：Metabolic Brain Disease, 2009, 24(4): 673-684.

DOI：10.1007/s11011-009-9169-y

• Choroid plexus
• Iron transport
• Blood brain barrier
• Blood-CSF barrier
• Ferroportin
• Ceruloplasmin

Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.

• 出版日期2009-12