Aethusifolins A-D: Four new components from a traditional Mongolian medicinal herb Clematis aethusifolia Turcz

作者：Chang, Yanxi; Zhang, Ping; Jurhiin, Jirimubatu; Zhang, Xuan; Borgihiin, Wuyahan; Zhao, Hongmei; Koo, Sangho; Rausch, Wolf-Dieter; Agula, B.; Bao, Baoquan^*

来源：Phytochemistry Letters, 2017, 22: 87-91.

DOI：10.1016/j.phytol.2017.09.012

• Clematis aethusifolia
• Chemical constituents
• Cytotoxicity
• Traditional mongolian medicine

Four new components named aethusifolins A-D (1-4), together with ten known (5-14) were isolated from the dried aerial parts of a traditional Mongolian medicinal herb Clematis aethusifolia Turcz. The planar structures were established based on extensive spectroscopic analysis (HRMS, 1D and 2D NMR), and the absolute configurations were determined by modified Mosher's method, hydrolysis method. The cytotoxicities of isolated compounds against a panel of five human solid tumor cell lines were assayed. Compounds 5, 8, and 13 showed moderate cytotoxicity against A-375 with IC50 values of 15-18 mu M, while compound 8 also showed cytotoxicity against SH-SY5Y with IC50 values of 20 mu M.

• 出版日期2017-12
• 单位内蒙古医科大学