Assessment of micronuclei and sister chromatid exchange frequency in the petroleum industry workers in province of Vojvodina, Republic of Serbia

作者：Mrdjanovic Jasminka; Solajic Slavica; Dimitrijevic Sladjana; Dan Igor; NikolicA Ivan; Jurisic Vladimir^*

来源：Food and Chemical Toxicology, 2014, 69: 63-68.

DOI：10.1016/j.fct.2014.03.041

• Micronuclei
• Sister chromatid exchange
• Proliferative index
• Petroleum refinery
• Risk
• Cigarette smoking

Persons who work with petroleum and petroleum derivatives (PPD) are potentially at risk of developing cancer mostly due to the carcinogenity of benzene. Therefore, the aim of this study was to determine in which degree occupational exposure of workers to PPD causes damage to DNA by analysis of micronuclei (MN), sister chromatid exchanges (SCE) and proliferation index (PI). 30 workers of refinery in Novi Sad, participated in the study as exposed and 30 volunteers as control group. Workers exposed to PPD had significantly higher values of MN and SCE in comparison to controls. Exposition time to PPD and type of working place have also significantly effects to DNA damage. The influence of confounding factor such as smoking and age were also evaluated.

• 出版日期2014-7