Near Room Temperature Cross-Coupling Reactions of Arene Boronic Acids with a Quinoxaline 1,4-Dioxide Benzylsulfanyl Derivative

作者：Dahbi Samir; Bisseret Philippe^*

来源：European Journal of Organic Chemistry, 2012, (20): 3759-3763.

DOI：10.1002/ejoc.201200433

• Heterocycles
• Nitrogen oxides
• Cross-coupling
• Boron
• Copper

A new quinoxaline 1,4-dioxide benzylsulfanyl derivative was tested under mild conditions in copper-mediated LiebeskindSrogl (LS) cross-coupling reactions with arene boronic acids. These first organometallic cross-coupling reactions performed on a quinoxaline 1,4-dioxide derivative open new perspectives in medicinal chemistry. They represent also the first LS cross-couplings run with an electrophile equipped with an aryl N-oxide moiety.

• 出版日期2012-7