An efficient kinetic resolution of racemic betti base based on an enantioselective N,O-deketalization

作者：Dong YM; Li R; Lu J; Xu XN; Wang XY; Hu YF^*

来源：Journal of Organic Chemistry, 2005, 70(21): 8617-8620.

DOI：10.1021/jo051328j

[GRAPHIC]
An efficient kinetic resolution of racemic Betti base with L-(+)-tartaric acid in acetone was developed based on a novel enantioselective N,O-deketalization, by which the enantiopure R- and S-enantiomers of Betti base were obtained as the corresponding NO-ketal compound and salt with L-(+)-tartaric acid, respectively, in excellent yields with a practically foolproof operation.

• 出版日期2005-10-14
• 单位清华大学