Association Between Mannose-Binding Lectin Gene Polymorphisms and Pre-eclampsia in Brazilian Women

作者：Vianna Priscila; da Silva Gabriela Kniphoff; dos Santos Bruno Paiva; Bauer Moises Evandro; Dalmaz Caroline Abrao; Bandinelli Eliane; Bogo Chies Jose Artur

来源：American Journal of Reproductive Immunology, 2010, 64(5): 359-366.

DOI：10.1111/j.1600-0897.2010.00846.x

• Inflammation
• MBL polymorphisms
• pre-eclampsia

Problem
Mannose-binding lectin (MBL) is involved in the maintenance of an inflammatory environment in uterus. High MBL levels have been associated with successful pregnancies whereas low levels are involved in pre-eclampsia (PE) development. Here, we evaluated MBL2 gene polymorphisms in the structural and promoter regions addressing their association with PE.
Method of study
DNA samples from 162 control pregnant women and 157 pregnant PE women were genotyped and data compared with demographic and clinical characteristics.
Results
High frequency of C and D alleles (related to low MBL levels) was observed in PE women when compared to controls (C: 0.08 versus 0.03, P = 0.006; D: 0.10 versus 0.05, P = 0.009). Grouping the MBL genotypes according to phenotype, a higher frequency of OO genotype was observed in PE women when compared to control women (0.15 versus 0.04, P = 0.007).
Conclusion
Our data suggest that women with genotypes associated with low MBL levels could be potential PE developers.

• 出版日期2010-11