Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease

作者：Greer Laura G^*; Casey Brian M; Halvorson Lisa M; Spong Catherine Y; McIntire Donald D; Cunningham F Gary

来源：American Journal of Obstetrics and Gynecology, 2011, 205(5): 471.e1.

DOI：10.1016/j.ajog.2011.06.060

• autoimmune thyroid disease
• microchimerism
• thyroid peroxidase antibody

OBJECTIVE: Fetal microchimerism may have a role in development of autoimmune thyroid disorders. Using parity as a surrogate for increasing fetal cell exposure, we analyzed its association with thyroid peroxidase antibody levels.
STUDY DESIGN: Secondary analysis of serum thyroid analytes determined in 17,298 women from a population-based prospective study between 2001 and 2003. Sera were assayed for thyrotropin, free thyroxine, and antithyroid peroxidase antibodies. We analyzed the relationship between thyroid peroxidase antibodies and increasing parity.
RESULTS: The incidence of abnormally elevated thyroid peroxidase antibody levels (>50 IU/mL) increased with advancing parity, but was not significant after adjustment for maternal characteristics. However, at higher thyroid peroxidase antibody levels (>500 IU/mL), a significant relationship with advancing parity persisted after adjustments (P = .002).
CONCLUSION: Advancing parity is associated with an increased risk for high serum concentrations of antithyroid peroxidase antibodies. This suggests fetal microchimerism may play a role in development of autoimmune thyroid disorders.

• 出版日期2011-11