Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

作者：Anto Josep M^*; Pinart Mariona; Akdis Muebeccel; Auffray Charles; Bachert Claus; Basagana Xavier; Carlsen Kai Hakon; Guerra Stefano; von Hertzen Leena; Illi Sabina; Kauffmann Francine; Keil Thomas; Kiley James P; Koppelman Gerard H; Lupinek Christian; Martinez Fernando D; Nawijn Martijn C; Postma Dirkje S; Siroux Valerie; Smit Henriette A; Sterk Peter J; Sunyer Jordi; Valenta Rudolf; Valverde Sergio; Akdis Cezmi A; Annesi Maesano Isabella; Ballester Ferran

来源：Journal of Allergy and Clinical Immunology, 2012, 129(4): 943-U421.

DOI：10.1016/j.jaci.2012.01.047

• Allergy
• Mechanisms of the Development of Allergy
• Seventh Framework Program
• phenotypes
• IgE
• asthma

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)

• 出版日期2012-4