A simple microwave-assisted preparation of 2-bromo-1-alkenes from 1-alkynes using the LiBr-TMSCl-TEAB reagent system

作者：Bunrit Anon; Ruchirawat Somsak; Thongsornkleeb Charnsak^*

来源：Tetrahedron Letters, 2011, 52(24): 3124-3127.

DOI：10.1016/j.tetlet.2011.04.025

2-Bromo-1-alkenes are cleanly and conveniently generated in good yields and selectivities via microwave-assisted hydrobromination of 1-alkynes using a combination of lithium bromide (LiBr), chlorotrimethylsilane (TMSCl), and tetraethylammonium bromide (TEAB) in acetonitrile (MeCN).

• 出版日期2011-6-15