Anti-Yo positive and late-onset paraneoplastic cerebellar degeneration associated with ovarian carcinoma A case report

作者：Cui, Dan; Xu, Li; Li, Wen-Yi; Qian, Wei-Dong^*

来源：Medicine, 2017, 96(32): e7362.

DOI：10.1097/MD.0000000000007362

• anti-Yo
• neurological complication
• ovarian carcinoma
• paraneoplastic cerebellar degeneration

Rationale: Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication often associated with ovarian, breast, and other gynecologic cancers. Anti-Yo is one of the antionconeural antibodies found in patients with PCD. It primarily emerges before a malignancy is detected.
Patient concerns: In this report, we describe an unusual case involving a patient who exhibited anti-Yo-positive PCD 1 year after being diagnosed with ovarian cancer.
Diagnoses: Histopathology of the resected tissues and Antineuronal antibody testing.
Interventions: The patient was treated with intravenous immunoglobulin (IVIG, 1g/d) for 1 week and a large-dose of methylprednisolone (0.4 g/kg/d) for 5 days. At the same time, underlying complications were prevented actively, and the peripheral nerves were protected.
Outcomes: Although most patients with anti-Yo-positive PCD do not improve after treatment, our patient significantly improved after receiving active and effective treatment.

• 出版日期2017-8
• 单位蚌埠医学院