Assessment of Genetic Contributions to Risk of Preeclampsia in Ecuadorian Women

作者：Lopez Pulles Ramiro; Gonzalez Andrade Fabricio^*; Duran Rodas Mario; Ayala Jose; Carrillo Richard; Rene Buitron Luis; Chuga Juan; Moya Walter

来源：Hypertension in Pregnancy, 2010, 29(4): 410-418.

DOI：10.3109/10641950903572258

• Eclampsia
• Etiology
• Familial history Genetic factors Physiopathology
• Preeclampsia

Aim To identify the immunogenetic factors that trigger the beginning of preeclampsia and eclampsia Methods A retrospective case control study of 142 pregnant women in Obstetrics and Gynecological Hospital Isidro Ayora in Quito, who are grouped into two different groups, diseased and healthy The study analyzed ethnicity, age, gynecological history, contraception, immunizations blood type and Rh factor, and family history of preeclampsia eclampsia of each of the pregnant women and gestational age, sex, weight, and blood type and Rh factor of the progeny Results Age ethnicity, history of pregnancy, abortions, contraception, and blood type and Rh factor were similar for both groups (p > 0 05) Gestational age and weight of the progeny was lower in cases compared with controls (p < 0 05) There was no statistical difference when corn paring the blood type and Rh factor of the two groups (p > 0 05) Male gender was predominant in both groups for cases 69 01 and 87 32% for controls (p < 0 05) Conclusions There was a higher predisposition for inherited cases (26%) versus controls (9 85%), p < 0 05, for the occurrence of preeclampsia The frequency of the recessive gene for Mendelian inheritance model mother fetus homozygous (aa/aa), in agreement with the Hardy Weinberg Law, was 0 41 for the sample

• 出版日期2010