Mild Rhodium(III)-Catalyzed C-H Allylation with 4-Vinyl-1,3-dioxolan-2-ones: Direct and Stereoselective Synthesis of (E)-Allylic Alcohols

作者：Zhang, Shang-Shi; Wu, Jia-Qiang; Lao, Ye-Xing; Liu, Xu-Ge; Liu, Yao; Lv, Wen-Xin; Tan, Dong-Hang; Zeng, Yao-Fu; Wang, Honggen^*

来源：Organic Letters, 2014, 16(24): 6412-6415.

DOI：10.1021/ol503229c

• ELECTRON-DEFICIENT ARENES
• N BOND FORMATION
• ALLYLIC ALCOHOLS
• COUPLING REACTION
• VINYL EPOXIDES
• PALLADIUM
• ACTIVATION
• CARBONATES
• CHEMISTRY
• ARYLATION

A rhodium(III)-catalyzed CH direct allylation reaction with 4-vinyl-1,3-dioxolan-2-ones has been developed. The reaction provides a facile and stereoselective access to substituted-(E)-allylic alcohols under mild and redox-neutral reaction conditions. Olefinic CH activation is applicable, giving multifunctionalized skipped dienes in good yields. Minimal double-bond migration was observed.

• 出版日期2014-12-19
• 单位中山大学