科研之友
微信
新浪微博
Facebook
分享链接
摘要
This communication describes a new method for the Pd/polrxometalate-catalyzed aerobic olefination of unactivated sp(3)C H bonds. Nitrogen heterocycles serve as directing groups, and air is used as the terminal oxidant. The products undergo reversible intramolecular Michael addition, which protects the monoalkenylated product from overfunctionalization. Hydrogenation of the Michael adducts provides access to bicyclic nitrogen-containing scaffolds that are prevalent in alkaloid natural products. Additionally, the cationic Michael adducts undergo facile elimination to release alpha,beta-unsaturated olefins, which can be further elaborated via C-C and C-heteroatom bond-forming reactions.
- 出版日期2011-5-4
