Dermal Titanium Dioxide Deposition Associated With Intralesional Triamcinolone Injection

作者：Cohen Brandon E; Bashey Sameer; Cole Christine; Abraham Jerrold L; Ragsdale Bruce; Ngo Binh^*

来源：American Journal of Dermatopathology, 2016, 38(12): E163-E166.

DOI：10.1097/dad.0000000000000623

• intralesional triamcinolone
• titanium dioxide
• scanning electron microscopy

Cutaneous discoloration secondary to dermal deposition of titanium dioxide (TiO2) particles is recognized but seldom reported in the literature. In this report, the authors describe the case of a 61-year-old gentleman, with a long history of alopecia areata, who presented with numerous, discrete dark blue macules on the scalp. Scanning electron microscopy with energy dispersive x-ray spectroscopy analysis ultimately identified the macules as deposits of TiO2. The patient had a history of intralesional triamcinolone injections for management of alopecia areata. A sample of generic 0.1% triamcinolone acetonide paste was analyzed and found to contain many TiO2 particles analogous to those seen in the patient's biopsy sample. To the authors' knowledge, this is the first reported case of TiO2 deposition in the dermis likely resulting from topical combined with intralesional triamcinolone injection.

• 出版日期2016-12