A Practical and Chemoselective Ammonia-Free Birch Reduction

作者：Lei, Peng; Ding, Yuxuan; Zhang, Xiaohe; Adijiang, Adila; Li, Hengzhao; Ling, Yun; An, Jie^*

来源：Organic Letters, 2018, 20(12): 3439-3442.

DOI：10.1021/acs.orglett.8b00891

• SILICA-GEL
• ALKALI-METALS
• AROMATIC-COMPOUNDS
• ELECTRON-TRANSFER
• AMINOKETYL RADICALS
• REDUCING AGENTS
• KETYL RADICALS
• HYDROCARBONS
• HYDROGEN
• SMI2-H2O

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.

• 出版日期2018-6-15
• 单位中国农业大学