Acquired Infantile Abducens Palsy Associated With Anti-GM2 Antibodies

作者：Smyth Kim A; Fritzler Marvin J; Kirton Adam^*

来源：Pediatric Neurology, 2011, 44(6): 459-462.

DOI：10.1016/j.pediatrneurol.2011.01.021

Anti-ganglioside antibodies have been associated with acquired neuropathies, including Gullain-Barre syndrome. We describe a case of acute abducens nerve palsy acquired 2 weeks after symptoms of upper respiratory tract infection and rash in a 6-month-old. Elevated anti-GM2 ganglioside immunoglobulin M antibodies were detected in the serum. The palsy slowly improved over time, although eventually surgical intervention was required. Elevated anti-GM2 immunoglobulin M antibodies have previously been reported in Guillain-Barre syndrome variants involving sensory and cranial neuropathies, but never in isolated unilateral cranial nerve VI mononeuropathy. Anti-ganglioside antibodies may play a role in the pathogenesis of postinfectious isolated abducens palsy in young children.

• 出版日期2011-6