Diterpenes from buds of Wikstroemia chamaedaphne showing anti-hepatitis B virus activities

作者：Li, Shi-Fei^*; Jiao, Ying-Ying; Zhang, Zhi-Qiang; Chao, Jian-Bin; Jia, Jie; Shi, Xun-Long^*; Zhang, Li-Wei^*

来源：Phytochemistry, 2018, 151: 17-25.

DOI：10.1016/j.phytochem.2018.01.021

• Wikstroemia chamaedaphne Meisn.
• Thymelaeaceae
• anti-Hepatitis B virus
• Tigliane diterpene
• Daphnane diterpene
• Lathyrane diterpene

Phytochemical study of the buds of Wikstroemia chamaedaphne Meisn. led to the isolation of seven previously undescribed diterpenes, including one tigliane diterpene (wikstchalide A), two daphnane diterpenes (wikstroelides W-X), and four lathyrane diterpenes (laurifoliosides A-B and 2-epi-laurifoliosides A-B), along with four known diterpenes. The structures of these compounds were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Wikstchalide A possesses a 5,6-epoxy ring in the tigliane skeleton. Two compounds exhibited potential anti-hepatitis B virus activities, with IC50 values of 46.5 and 88.3 mu g/mL against hepatitis B virus (HBV) surface antigen (HBsAg), and six compounds showed certain inhibitory effects on HBV-DNA replication with the inhibition ratios ranging from 2.0% to 33.0% at the concentrations ranging from 0.39 to 6.25 mu g/mL.

• 出版日期2018-7
• 单位复旦大学; 山西大学