Absorption and disposition of florfenicol after intravenous, intramuscular and subcutaneous dosing in alpacas

作者：Pentecost Rebecca L; Niehaus Andrew J; Werle Nicholas; Lakritz Jeffrey^*

来源：Research in Veterinary Science, 2015, 99: 199-203.

DOI：10.1016/j.rvsc.2015.02.006

• Florfenicol
• Pharmacokinetics
• Intravenous
• Intramuscular
• Subcutaneous
• Bioavailability
• Absorption time

The objectives of this study were to define disposition and systemic availability of florfenicol in alpacas. Administration of 20 mg/kg doses to 8 male alpacas by i.v., i.m. and s.c. routes was performed by randomized, 3-way crossover design. Clearance and steady state volumes (Vd(ss)) after i.v. injection were 5 ml/min/kg and 775 ml/kg respectively. Mean residence time (MRT) and terminal phase half-life (T-1/2 lambda(z)) were 2.8 h and 2 h respectively. Maximum serum concentrations (C-max) after i.m. were higher than s.c. administration (p = 0.034). After s.c. dosing, T-1/2 lambda(z) and MRT were greater than after i.m. injection (p < 0.001; p = 0.006 respectively). Mean absorption time (MAT) after s.c. dosing was also prolonged (p = 0.006). Fractional absorption of florfenicol after i.m. and s.c. was not different (p > 0.05). Serum florfenicol concentrations remained >1.0 mu g/ml for 20 h after i.m. dosing. Differences in rate and extent of florfenicol absorption after extravascular dosing could influence therapeutic outcomes.

• 出版日期2015-4