A beta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3 beta

作者：Jo Jihoon; Whitcomb Daniel J; Olsen Kimberly Moore; Kerrigan Talitha L; Lo Shih Ching; Bru Mercier Gilles; Dickinson Bryony; Scullion Sarah; Sheng Morgan; Collingridge Graham; Cho Kwangwook^*

来源：Nature Neuroscience, 2011, 14(5): 545-547.

DOI：10.1038/nn.2785

Amyloid-beta(1-42) (A beta) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of A. to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3b is an important mediator of this effect in rats and mice.

• 出版日期2011-5