Anti-cytomegalovirus effects of tricin are dependent on CXCL11

作者：Murayama Tsugiya^*; Li Ying; Takahashi Takashi; Yamada Rie; Matsubara Keiko; Tuchida Yuuzo; Li Zhuan; Sadanari Hidetaka

来源：Microbes and Infection, 2012, 14(12): 1086-1092.

DOI：10.1016/j.micinf.2012.05.017

• Anti-cytomegalovirus activity
• Tricin
• CXCL11
• SiRNA
• Chemokine

It has been reported that treatment with tricin (4%26apos;,5,7-trihydroxy-3%26apos;,5%26apos;-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin.

• 出版日期2012-10