Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

作者：Yi Cecilia Arana; Jeyakumar Ghayathri; Medina Pedro; Cortes Jorge; Pierce Sherry; Bueso Ramos Carlos; Kantarjian Hagop; Verstovsek Srdan^*

来源：Leukemia Research, 2014, 38(1): 91-94.

DOI：10.1016/j.leukres.2013.11.002

• Primary myelofibrosis
• Diagnostic discrepancy
• JAKV617F mutation

Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70(12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

• 出版日期2014-1