Decision-making in geriatric oncology: systemic treatment considerations for older adults with colon cancer

作者：Moth Erin B; Vardy Janette; Blinman Prunella^*

来源：Expert Review of Gastroenterology and Hepatology, 2016, 10(12): 1321-1340.

DOI：10.1080/17474124.2016.1244003

• Colon cancer
• chemotherapy
• decision-making
• older adult

Introduction: Colon cancer is common and can be considered a disease of older adults with more than half of cases diagnosed in patients aged over 70years. Decision-making about treatment with chemotherapy for older adults may be complicated by age-related physiological changes, impaired functional status, limited social supports, concerns regarding the occurrence of and ability to tolerate treatment toxicity, and the presence of comorbidities. This is compounded by a lack of high quality evidence guiding cancer treatment decisions for older adults.Areas covered: This narrative review evaluates the evidence for adjuvant and palliative systemic therapy in older adults with colon cancer. The value of an adequate assessment prior to making a treatment decision is addressed, with emphasis on the geriatric assessment. Guidance in making a treatment decision is provided.Expert commentary: Treatment decisions should consider goals of care, a patient's treatment preferences, and weigh up relative benefits and harms.

• 出版日期2016-12