A peptide vaccine based on a B-cell epitope on the VP1 protein of enterovirus 70 induces a strong antibody response

作者：Park Kee Bum; Lim Byung Kwan; Ye Michael B; Chung Soo Young; Nam Jae Hwan^*

来源：Acta Virologica, 2012, 56(4): 337-342.

DOI：10.4149/av_2012_04_337

• enterovirus 70
• AHC
• B-cell epitope
• peptide vaccine

Enterovirus 70 (EV70) is the causative agent of acute hemorrhagic conjunctivitis (AHC), for which no effective vaccine is available. This study revealed a high reactivity of the N-terminal region of EV70 VP1 (VP1-1) with an anti-EV70 mouse serum. The analysis of overlapping synthetic peptides of VP1-1 identified a B-cell epitope in this region. The E-peptide (14-ANTVESEIKAELGVI-28) showing the highest reactivity with the anti-EV70 serum induced neutralizing antibodies in mice and reduced the virus titer in the eyes, suggesting that it is a candidate vaccine against AHC caused by EV70.

• 出版日期2012