Acceleration of calcium phosphate formation on bioactive PMMA-based bone cement by controlling spatial design

作者：Totani Yuki; Sugino Atsushi; Miyazaki Toshiki^*; Ohtsuki Chikara

来源：Materials Science and Engineering: C , 2010, 30(4): 624-630.

DOI：10.1016/j.msec.2010.02.018

• Apatite
• PMMA bone cement
• Simulated body fluid (SBF)
• Spatial design
• Bioactivity

Polymethylmethacrylate (PMMA)-based bone cement is widely used for the fixation of artificial joints. However, it is not considered a bioactive material because it lacks the ability to induce a direct bond with bone. In order to improve the long-term stability of cemented fixations, the development of bioactive bone cements is desirable. An essential requirement of a bioactive material includes the induction of bone-like apatite on its surface within the in vivo environment. Previously, we prepared bioactive PMMA-based bone cements by a modification with water-soluble calcium salts and alkoxysilane. Because spatial design may enhance apatite formation on bioactive material surfaces in vivo. we aimed to evaluate the effect of spatial design on apatite formation on modified PMMA-based bone cements in simulated body fluid (SBF). We found that an appropriate spatial design shortened the induction period for the apatite deposition on the modified bone cements. It is expected that osteoconduction would be enhanced in spontaneously created gap between the cement and the host bone leading to tight integration.

• 出版日期2010-5-10