Asymmetric Synthesis of Chiral delta-Lactones Containing Multiple Contiguous Stereocenters

作者：Peed Jennifer; Dominguez Ignacio Perinan; Davies Iwan R; Cheeseman Matt; Taylor James E; Kociok Koehn Gabriele; Bull Steven D^*

来源：Organic Letters, 2011, 13(14): 3592-3595.

DOI：10.1021/ol2012023

A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.

• 出版日期2011-7-15