Altered phenotype and function of NK cells infiltrating Human Papillomavirus (HPV)-associated genital warts during HIV infection

作者：Bere Alfred; Tayib Shahila; Kriek Jean Mari; Masson Lindi; Jaumdally Shameem Z; Barnabas Shaun L; Carr William H; Allan Bruce; Williamson Anna Lise; Denny Lynette; Passmore Jo Ann S^*

来源：Clinical Immunology, 2014, 150(2): 210-219.

DOI：10.1016/j.clim.2013.12.005

• Genital warts
• Mucosal
• HPV
• HIV
• NK cells

HIV-infected individuals experience more persistent HPV infections and are less likely to resolve genital warts. This study compared phenotype and functions of NK and T cells from genital warts and blood from 67 women. We compared in vitro functional responses of NK and T cells by multiparametric flow cytometry. HIV+ women had significantly lower frequencies of CD4 T cells in warts (p = 0.001) and blood (p = 0.001). While the distribution of NK cell subsets was similar, HIV+ women tended to have lower frequencies of CD56(Dim) NK cells in both blood (p = 0.0001) and warts (p = 0.006) than HIV women. Wart NK cells from HIV+ women expressed significantly lower CD107a and produced IFN-gamma. HAART status was not associated with differences in NK cell functionality. We conclude that wart NK cells from HIV+ women have defects in their ability to degranulate and/or secrete IFN-gamma, which may provide insights into why HIV+ women fail to spontaneously resolve genital warts.

• 出版日期2014-2