Macrolides: The Plug Is Out

作者：Gamerdinger Martin; Deuerling Elke^*

来源：Cell, 2012, 151(3): 469-471.

DOI：10.1016/j.cell.2012.10.015

Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.

• 出版日期2012-10-26