An unexpected role for MHC class II

作者:Hassan Ghada S*; Mourad Walid
来源:Nature Immunology, 2011, 12(5): 375-376.
DOI:10.1038/ni.2023

摘要

In addition to their classical function in antigen presentation and their lesser known ability to act as signal transducers, major histocompatibility complex class II molecules are now shown to promote Toll-like receptor signaling. This intriguing role requires intracellular association with the kinase Btk and the costimulatory molecule CD40.

  • 出版日期2011-5